Article
Molecular Basis for Dysregulated Activation of NKX2-5 in the Vascular Remodeling of Systemic Sclerosis.
Arthritis & rheumatology (Hoboken, N.J.) - 1 Jun 2018
Dritsoula Athina, Papaioannou Ioannis, Guerra Sandra G, Fonseca Carmen, Martin Javier, Herrick Ariane L, Abraham David J, Denton Christopher P, Ponticos Markella
Abstract excerpt
OBJECTIVE: NKX2-5 is a homeobox transcription factor that is required for the formation of the heart and vessels during development, with significant postnatal down-regulation and reactivation in disease states, characterized by vascular remodeling. The purpose of this study was to investigate mechanisms that activate NKX2-5 expression in diseased vessels, such as systemic sclerosis (scleroderma; SSc)-associated...
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