Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system.

doi:10.1128/MCB.23.18.6662-6671.2003

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Article

Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system.

Molecular and cellular biology - 1 Sept 2003

Sato Naoto, Kawahara Hiroyuki, Toh-e Akio, Maeda Tatsuya

Abstract excerpt

In Saccharomyces cerevisiae, a phosphorelay signal transduction pathway composed of Sln1p, Ypd1p, and Ssk1p, which are homologous to bacterial two-component signal transducers, is involved in the osmosensing mechanism. In response to high osmolarity, the phosphorelay system is inactivated and Ssk1p remains unphosphorylated. Unphosphorylated Ssk1p binds to and activates the Ssk2p mitogen-activated protein (MAP)...

Topics

Biological Transport
Cysteine Endopeptidases
DNA-Binding Proteins
Down-Regulation
Intracellular Signaling Peptides and Proteins
Ligases
MAP Kinase Kinase Kinases
MAP Kinase Signaling System
Multienzyme Complexes
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Osmosis

Phosphorylation

Proteasome Endopeptidase Complex

Protein Kinases

Protein Serine-Threonine Kinases

Protein Structure, Tertiary

Saccharomyces cerevisiae

Saccharomyces cerevisiae Proteins

Source

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Identifiers

PMID: 12944490
DOI: 10.1128/MCB.23.18.6662-6671.2003
PMCID: PMC193698

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-12944490-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Phosphorelay-regulated degradation of the yeast Ssk1p response regulator by the ubiquitin-proteasome system.PMID 12944490Read ↗

Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 "two-component" osmosensor.Semantic proximity Read ↗

Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator.Semantic proximity Read ↗

Phosphorylated Ssk1 prevents unphosphorylated Ssk1 from activating the Ssk2 mitogen-activated protein kinase kinase kinase in the yeast high-osmolarity glycerol osmoregulatory pathway.Semantic proximity Read ↗

Activation of the Hog1 MAPK by the Ssk2/Ssk22 MAP3Ks, in the absence of the osmosensors, is not sufficient to trigger osmostress adaptation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Ssk1p-independent activation of Ssk2p plays an important role in the osmotic stress response in Saccharomyces cerevisiae: alternative activation of Ssk2p in osmotic stress.Semantic proximity Read ↗

Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK.Semantic proximity Read ↗

Transmembrane mucins Hkr1 and Msb2 are putative osmosensors in the SHO1 branch of yeast HOG pathway.Semantic proximity Read ↗

Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases.Semantic proximity Read ↗

Unique and redundant roles for HOG MAPK pathway components as revealed by whole-genome expression analysis.Semantic proximity Read ↗

Yeast Skn7p activity is modulated by the Sln1p-Ypd1p osmosensor and contributes to regulation of the HOG pathway.Semantic proximity Read ↗

Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor.Semantic proximity Read ↗

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase.Semantic proximity Read ↗

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