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Article

The impact of diuretic use and ABCG2 genotype on the predictive performance of a published allopurinol dosing tool.

British journal of clinical pharmacology - 1 May 2018

Wright Daniel F B, Dalbeth Nicola, Phipps-Green Amanda J, Merriman Tony R, Barclay Murray L, Drake Jill, Tan Paul, Horne Anne, Stamp Lisa K

Abstract excerpt

AIM: This research aims to evaluate the predictive performance of a published allopurinol dosing tool. METHODS: Allopurinol dose predictions were compared to the actual dose required to achieve serum urate (SU) <0.36 mmol l-1 using mean prediction error. The influence of patient factors on dose predictions was explored using multilinear regression. RESULTS: Allopurinol doses were overpredicted by the dosing tool;...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29341237
DOI: 10.1111/bcp.13516
PMCID: PMC5903228

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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