Article
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Nature - 14 Aug 2011
Siracusa Mark C, Saenz Steven A, Hill David A, Kim Brian S, Headley Mark B, Doering Travis A, Wherry E John, Jessup Heidi K, Siegel Lori A, Kambayashi Taku, Dudek Emily C, Kubo Masato, Cianferoni Antonella, Spergel Jonathan M, Ziegler Steven F, Comeau Michael R, Artis David
Abstract excerpt
CD4(+) T-helper type 2 (T(H)2) cells, characterized by their expression of interleukin (IL)-4, IL-5, IL-9 and IL-13, are required for immunity to helminth parasites and promote the pathological inflammation associated with asthma and allergic diseases. Polymorphisms in the gene encoding the cytokine thymic stromal lymphopoietin (TSLP) are associated with the development of multiple allergic disorders in humans,...
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