Article
TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation.
Nature - 14 Aug 2011
Siracusa Mark C, Saenz Steven A, Hill David A, Kim Brian S, Headley Mark B, Doering Travis A, Wherry E John, Jessup Heidi K, Siegel Lori A, Kambayashi Taku, Dudek Emily C, Kubo Masato, Cianferoni Antonella, Spergel Jonathan M, Ziegler Steven F, Comeau Michael R, Artis David
Abstract excerpt
CD4(+) T-helper type 2 (T(H)2) cells, characterized by their expression of interleukin (IL)-4, IL-5, IL-9 and IL-13, are required for immunity to helminth parasites and promote the pathological inflammation associated with asthma and allergic diseases. Polymorphisms in the gene encoding the cytok...
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