Article
HLA Association with Drug-Induced Adverse Reactions.
Journal of immunology research - 1 Jan 2017
Fan Wen-Lang, Shiao Meng-Shin, Hui Rosaline Chung-Yee, Su Shih-Chi, Wang Chuang-Wei, Chang Ya-Ching, Chung Wen-Hung
Abstract excerpt
Adverse drug reactions (ADRs) remain a common and major problem in healthcare. Severe cutaneous adverse drug reactions (SCARs), such as Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with mortality rate ranges from 10% to more than 30%, can be life threatening. A number of recent studies demonstrated that ADRs possess strong genetic predisposition. ADRs induced by several drugs have been shown to...
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