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Digital PCR for determination of cytochrome P450 2D6 and sulfotransferase 1A1 gene copy number variations.

Drug discoveries & therapeutics - 1 Jan 2000

Motoi Yutaro, Watanabe Kazufumi, Honma Hiroyuki, Tadano Yousuke, Hashimoto Hiroshi, Kubota Takahiro

Abstract excerpt

CYP2D6 and SULT1A1 occasionally show copy number variations (CNVs), with a larger number generally indicating greater enzymic activity. However, those variations are difficult to calculate using standard methods. With digital PCR, a recently introduced method for CNV analysis, DNA molecules are subjected to limited dilution and separated into nano-scale droplets prior to a PCR assay. Absolute quantitation of copy...

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PMID: 29332892
DOI: 10.5582/ddt.2017.01057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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