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Article

Noninvasive and Accurate Detection of Hereditary Hearing Loss Mutations with Buccal Swab Based on Droplet Digital PCR.

Analytical chemistry - 7 Aug 2018

Wang Fang, Zhu Lingxiang, Liu Baoxia, Zhu Xiurui, Wang Nan, Deng Tao, Kang Dongyang, Pan Junmin, Yang Wenjun, Gao Huafang, Guo Yong

Abstract excerpt

Hereditary hearing loss is a common clinical neurosensory disorder in humans and has a high demand for genetic screening. Current screening techniques using peripheral blood or dried blood spots (DBSs) are invasive. Therefore, this study aims to develop a noninvasive and accurate detection method for eight hotspot deafness-associated mutations based on buccal swab and droplet digital PCR (ddPCR). First, this...

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Identifiers

PMID: 29987923
DOI: 10.1021/acs.analchem.8b01096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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