Recurrent inactivating RASA2 mutations in melanoma.

doi:10.1038/ng.3427

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Article

Recurrent inactivating RASA2 mutations in melanoma.

Nature genetics - 1 Dec 2015

Arafeh Rand, Qutob Nouar, Emmanuel Rafi, Keren-Paz Alona, Madore Jason, Elkahloun Abdel, Wilmott James S, Gartner Jared J, Di Pizio Antonella, Winograd-Katz Sabina, Sindiri Sivasish, Rotkopf Ron, Dutton-Regester Ken, Johansson Peter, Pritchard Antonia L, Waddell Nicola, Hill Victoria K, Lin Jimmy C, Hevroni Yael, Rosenberg Steven A, Khan Javed, Ben-Dor Shifra, Niv Masha Y, Ulitsky Igor, Mann Graham J, Scolyer Richard A, Hayward Nicholas K, Samuels Yardena

Abstract excerpt

Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and...

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Identifiers

PMID: 26502337
DOI: 10.1038/ng.3427
PMCID: PMC4954601

Genes

RASA2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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