Article
A cytosolic mutp53(E285K) variant confers chemoresistance of malignant melanoma.
Cell death & disease - 14 Dec 2023
Dunsche Luise, Ivanisenko Nikita, Riemann Shamala, Schindler Sebastian, Beissert Stefan, Angeli Cristian, Kreis Stephanie, Tavassoli Mahvash, Lavrik Inna, Kulms Dagmar
Abstract excerpt
Malignant melanoma (MM) is known to be intrinsically chemoresistant, even though only ~20% of MM carry mutations of the tumor suppressor p53. Despite improvement of systemic therapy the mortality rate of patients suffering from metastatic MM is still ~70%, highlighting the need for alternative treatment options or for the re-establishment of conventional therapeutic approaches, including chemotherapy. Screening...
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