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Article

Genetic variants in the genes encoding rho GTPases and related regulators predict cutaneous melanoma-specific survival.

International journal of cancer - 15 Aug 2017

Liu Shun, Wang Yanru, Xue William, Liu Hongliang, Xu Yinghui, Shi Qiong, Wu Wenting, Zhu Dakai, Amos Christopher I, Fang Shenying, Lee Jeffrey E, Hyslop Terry, Li Yi, Han Jiali, Wei Qingyi

Abstract excerpt

Rho GTPases control cell division, motility, adhesion, vesicular trafficking and phagocytosis, which may affect progression and/or prognosis of cancers. Here, we investigated associations between genetic variants of Rho GTPases-related genes and cutaneous melanoma-specific survival (CMSS) by re-analyzing a published melanoma genome-wide association study (GWAS) and validating the results in another melanoma GWAS....

Topics

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Gene Regulatory Networks
Genetic Association Studies
Melanoma
Melanoma, Cutaneous Malignant

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

rho GTP-Binding Proteins

Survival Analysis

Source

Open in PubMed Open full text

Identifiers

PMID: 28510328
DOI: 10.1002/ijc.30785
PMCID: PMC5512872

Genes

ARHGAP22
RHOU
ARHGAP44
ARHGEF10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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