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Crucial Roles of the Mesenchymal Androgen Receptor in Wolffian Duct Development

23 Dec 2023

Abstract excerpt

Wolffian duct (WD) maintenance and differentiation is predominantly driven by the androgen action, which is mediated by the androgen receptor (AR). It is well established that the mesenchyme indicates the fate and differentiation of epithelial cells. However, in vivo developmental requirement of mesenchymal AR in WD development is still undefined. By designing a mesenchyme-specific Ar knockout (ARcKO), we...

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PMID: 38146640
DOI: 10.1210/endocr/bqad193

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