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Article

Associations of plasma clusterin and Alzheimer's disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study.

PloS one - 1 Jan 2018

Haight Thaddeus, Bryan R Nick, Meirelles Osorio, Tracy Russell, Fornage Myriam, Richard Melissa, Nasrallah Ilya, Yaffe Kristine, Jacobs David R, Lewis Cora, Schreiner Pamela, Sidney Stephen, Davatzikos Christos, Launer Lenore J

Abstract excerpt

BACKGROUND: Clinical and epidemiological studies of older persons have implicated clusterin in Alzheimer's disease (AD) pathogenesis. In the context of identifying early biomarkers of risk, we examined associations of plasma clusterin and characteristics of AD in middle-aged individuals from the community. MATERIALS AND METHODS: Subjects were 639 cognitively normal individuals (mean age 50 ± 3.5) from the...

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PMID: 29324756
DOI: 10.1371/journal.pone.0190478
PMCID: PMC5764276

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