Article
Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.
Archives of general psychiatry - 1 Jul 2010
Thambisetty Madhav, Simmons Andrew, Velayudhan Latha, Hye Abdul, Campbell James, Zhang Yi, Wahlund Lars-Olof, Westman Eric, Kinsey Anna, Güntert Andreas, Proitsi Petroula, Powell John, Causevic Mirsada, Killick Richard, Lunnon Katie, Lynham Steven, Broadstock Martin, Choudhry Fahd, Howlett David R, Williams Robert J, Sharp Sally I, Mitchelmore Cathy, Tunnard Catherine, Leung Rufina, Foy Catherine, O'Brien Darragh, Breen Gerome, Furney Simon J, Ward Malcolm, Kloszewska Iwona, Mecocci Patrizia, Soininen Hilkka, Tsolaki Magda, Vellas Bruno, Hodges Angela, Murphy Declan G M, Parkins Sue, Richardson Jill C, Resnick Susan M, Ferrucci Luigi, Wong Dean F, Zhou Yun, Muehlboeck Sebastian, Evans Alan, Francis Paul T, Spenger Christian, Lovestone Simon
Abstract excerpt
CONTEXT: Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). OBJECTIVE: To identify plasma proteins associated with AD pathology using a combined proteomic and neuroimaging approach. DESIGN: Discovery-phase proteomics to identify plasma proteins associated with correlates of AD pathology. Confirmation and validation using immunodetection in a replication set and an animal...
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