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Brain and plasmatic CLUSTERIN are translational markers of Alzheimer's disease

22 Jun 2024

Abstract excerpt

Early diagnosis of late-onset Alzheimer's disease (AD) by peripheral biomarkers remains a challenge; many have been proposed, but none have been evaluated in a prospective manner. CLUSTERIN (CLU), a chaperone protein expressed in the brain and found in relatively high concentrations in plasma, is a promising candidate. CLU contributes to the elimination of β-amyloid (Aβ), which is associated to neurofibrillary...

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PMID: 39965636
DOI: 10.1111/bpa.13281

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