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Identification of Distinct Brain MRI Phenotypes and Their Association With Long-Term Dementia Risk in Community-Dwelling Older Adults.

Neurology - 9 Apr 2024

Keller Jasmin Annica, Sigurdsson Sigurdur, Schmitz Abecassis Bárbara, Kant Ilse M J, Van Buchem Mark A, Launer Lenore J, van Osch Matthias J P, Gudnason Vilmundur, de Bresser Jeroen

Abstract excerpt

BACKGROUND AND OBJECTIVES: Individual brain MRI markers only show at best a modest association with long-term occurrence of dementia. Therefore, it is challenging to accurately identify individuals at increased risk for dementia. We aimed to identify different brain MRI phenotypes by hierarchical clustering analysis based on combined neurovascular and neurodegenerative brain MRI markers and to determine the...

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PMID: 38471053
DOI: 10.1212/WNL.0000000000209176
PMCID: PMC11033985

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