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Article

Sharing of Phosphatases Promotes Response Plasticity in Phosphorylation Cascades.

Biophysical journal - 9 Jan 2018

Ghosh Bhaswar, Sarma Uddipan, Sourjik Victor, Legewie Stefan

Abstract excerpt

Sharing of positive or negative regulators between multiple targets is frequently observed in cellular signaling cascades. For instance, phosphatase sharing between multiple kinases is ubiquitous within the MAPK pathway. Here we investigate how such phosphatase sharing could shape robustness and evolvability of the phosphorylation cascade. Through modeling and evolutionary simulations, we demonstrate that 1)...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29320690
DOI: 10.1016/j.bpj.2017.10.037
PMCID: PMC5773761

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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