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Article

Contribution of Bistability and Noise to Cell Fate Transitions Determined by Feedback Opening.

Journal of molecular biology - 9 Oct 2016

Hsu Chieh, Jaquet Vincent, Maleki Farzaneh, Becskei Attila

Abstract excerpt

Alternative cell fates represent a form of non-genetic diversity, which can promote adaptation and functional specialization. It is difficult to predict the rate of the transition between two cell fates due to the strong effect of noise on feedback loops and missing parameters. We opened synthetic positive feedback loops experimentally to obtain open-loop functions. These functions allowed us to identify a...

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PMID: 27498164
DOI: 10.1016/j.jmb.2016.07.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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