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Article

Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade.

Current biology : CB - 26 Aug 2008

Takahashi Satoe, Pryciak Peter M

Abstract excerpt

BACKGROUND: Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show various input-output behaviors, including either switch-like or graded responses to increasing levels of stimulus. Prior studies suggest that switch-like behavior is promoted by positive feedback loops and nonprocessive phosphorylation reactions, but it is unclear whether graded signaling is a default behavior or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 18722124
DOI: 10.1016/j.cub.2008.07.050
PMCID: PMC2562168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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