Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade.

doi:10.1016/j.cub.2008.07.050

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Article

Membrane localization of scaffold proteins promotes graded signaling in the yeast MAP kinase cascade.

Current biology : CB - 26 Aug 2008

Takahashi Satoe, Pryciak Peter M

Abstract excerpt

BACKGROUND: Signaling through mitogen-activated protein kinase (MAPK) cascade pathways can show various input-output behaviors, including either switch-like or graded responses to increasing levels of stimulus. Prior studies suggest that switch-like behavior is promoted by positive feedback loops...

Topics

Adaptor Proteins, Signal Transducing
Cell Membrane
Genes, Fungal
MAP Kinase Signaling System
Mutation
Pheromones
Receptor Cross-Talk
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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