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Article

A mechanistic study of evolvability using the mitogen-activated protein kinase cascade.

Evolution & development - 1 Jan 2000

Nijhout H F, Berg A M, Gibson W T

Abstract excerpt

Evolvability is a function of the way genetic variation interacts with the mechanisms that produce the phenotype. We explore an explicitly mechanistic way of studying the evolvability of phenotypes that are produced by a relatively simple genetic mechanism, the mitogen-activated protein kinase (MAPK) cascade. We developed a quantitative model of MAPK activation that can be used to study the effects of genetic...

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Identifiers

PMID: 12752767
DOI: 10.1046/j.1525-142x.2003.03035.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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