Article
A Genome-Wide Association Study Identifies a Candidate Gene Associated With Atazanavir Exposure Measured in Hair.
Clinical pharmacology and therapeutics - 1 Nov 2018
Tamraz Bani, Huang Yong, French Audrey L, Kassaye Seble, Anastos Kathryn, Nowicki Marek J, Gange Stephen, Gustafson Deborah R, Bacchetti Peter, Greenblatt Ruth M, Hysi Pirro G, Aouizerat Bradley E
Abstract excerpt
Hair provides a direct measure of long-term exposure of atazanavir (ATV). We report the results of the first genome-wide association study (GWAS) of ATV exposure measured in hair in an observational cohort representative of US women living with HIV; the Women's Interagency HIV Study. Approximately 14.1 million single nucleotide polymorphisms (SNPs) were analyzed in linear regression-based GWAS, with replication,...
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