Article
A single-nucleotide polymorphism in CYP2B6 leads to >3-fold increases in efavirenz concentrations in plasma and hair among HIV-infected women.
The Journal of infectious diseases - 1 Nov 2012
Gandhi Monica, Greenblatt Ruth M, Bacchetti Peter, Jin Chengshi, Huang Yong, Anastos Kathryn, Cohen Mardge, Dehovitz Jack A, Sharp Gerald B, Gange Stephen J, Liu Chenglong, Hanson Susan C, Aouizerat Bradley
Abstract excerpt
BACKGROUND: Efavirenz exhibits marked interindividual variability in plasma levels and toxicities. Prior pharmacogenetic studies usually measure exposure via single plasma levels, examine limited numbers of polymorphisms, and rarely model multiple contributors. We analyzed numerous genetic and nongenetic factors impacting short-term and long-term exposure in a large heterogeneous population of human...
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