Article
Association of a single-nucleotide polymorphism in the pregnane X receptor (PXR 63396C-->T) with reduced concentrations of unboosted atazanavir.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 1 Nov 2008
Siccardi Marco, D'Avolio Antonio, Baietto Lorena, Gibbons Sara, Sciandra Mauro, Colucci Daniela, Bonora Stefano, Khoo Saye, Back David J, Di Perri Giovanni, Owen Andrew
Abstract excerpt
This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T-->C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.
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