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Article

CD19 Chimeric Antigen Receptor T Cells From Patients With Chronic Lymphocytic Leukemia Display an Elevated IFN-γ Production Profile.

Journal of immunotherapy (Hagerstown, Md. : 1997) - 1 Jan 2000

Magalhaes Isabelle, Kalland Ingrid, Kochenderfer James N, Österborg Anders, Uhlin Michael, Mattsson Jonas

Abstract excerpt

CD19 chimeric antigen receptor (CAR) T cell immunotherapy has demonstrated dramatic results for the treatment of B cell malignancies such as chronic lymphocytic leukemia (CLL). As T cell defects are common in patients with CLL, we compared the T cells from these patients with healthy donors (HDs), and subsequently the CD19 CAR T cells produced from patients and HDs. Despite initial differences when comparing the...

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Share to Antigens, CD19
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Immunotherapy, Adoptive

Share to Interferon-gamma

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Receptors, Antigen, T-Cell

Share to Receptors, Chimeric Antigen

Source

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Identifiers

PMID: 29315094
DOI: 10.1097/CJI.0000000000000193
PMCID: PMC8057115

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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