Article
Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity.
Oncotarget - 22 Sept 2015
Jabouille Arnaud, Delugin Maylis, Pineau Raphaël, Dubrac Alexandre, Soulet Fabienne, Lhomond Stéphanie, Pallares-Lupon Nestor, Prats Hervé, Bikfalvi Andreas, Chevet Eric, Touriol Christian, Moenner Michel
Abstract excerpt
IRE1α is an endoplasmic reticulum (ER)-resident transmembrane signaling protein and a cellular stress sensor. The protein harbors a cytosolic dual kinase/endoribonuclease activity required for adaptive responses to micro-environmental changes. In an orthotopic xenograft model of human glioma, invalidation of IRE1α RNase or/and kinase activities generated tumors with remarkably distinct phenotypes. Contrasting...
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