Article

IRE1 RNase controls CD95-mediated cell death

2022-02-26

Abstract excerpt

Signalling by the Unfolded Protein Response (UPR) or by the Death Receptors (DR) represents cellular stress pathways frequently activated towards pro-tumoral outputs in cancer. Experimental evidence has highlighted functional links between the UPR and the DR TRAIL-R1/2. Herein, we demonstrate that the UPR sensor IRE1 controls the expression of CD95/Fas, another DR, and its cell death-inducing ability. Whereas CD95...

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Literature Corpus work: aaeb6b06-d786-595f-b88f-5272212297f4
DOI: 10.1101/2022.02.25.481813

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