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Article

Distinct gene alterations with a high percentage of myeloperoxidase-positive leukemic blasts in de novo acute myeloid leukemia.

Leukemia research - 1 Feb 2018

Kamijo Rena, Itonaga Hidehiro, Kihara Rika, Nagata Yasunobu, Hata Tomoko, Asou Norio, Ohtake Shigeki, Shiraishi Yuichi, Chiba Kenichi, Tanaka Hiroko, Miyano Satoru, Ogawa Seishi, Naoe Tomoki, Kiyoi Hitoshi, Miyazaki Yasushi

Abstract excerpt

The myeloperoxidase (MPO)-positivity of blasts in bone marrow smears is an important marker for not only the diagnosis, but also the prognosis of acute myeloid leukemia (AML). To investigate the relationship between genetic alterations and MPO-positivity, we performed targeted sequencing for 51 genes and 10 chimeric gene transcripts in 164 newly diagnosed de novo AML patients; 107 and 57 patients were classified...

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Share to DNA Methylation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, Neoplasm

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Source

Identifiers

PMID: 29306105
DOI: 10.1016/j.leukres.2017.12.006

Genes

MPO
FLT3
IDH1
IDH2
KIT
RUNX1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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