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Article

Mutation profiling of 16 candidate genes in de novo acute myeloid leukemia patients.

Frontiers of medicine - 1 Apr 2019

Zhang Yang, Wang Fang, Chen Xue, Liu Wenjing, Fang Jiancheng, Wang Mingyu, Teng Wen, Cao Panxiang, Liu Hongxing

Abstract excerpt

This retrospective analysis aimed to investigate the mutation profile of 16 common mutated genes in de novo acute myeloid leukemia (AML) patients. A total of 259 patients who were diagnosed of de novo AML were enrolled in this study. Mutation profiling of 16 candidate genes were performed in bone marrow samples by using Sanger sequencing.We identified at least 1 mutation in 199 of the 259 samples (76.8%), and 2...

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Source

Identifiers

PMID: 29806051
DOI: 10.1007/s11684-018-0616-1

Genes

NPM1
FLT3
IDH2
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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