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SOX9 suppresses colon cancer via inhibiting epithelial-mesenchymal transition and SOX2 induction

3 Apr 2025

Abstract excerpt

The Wnt/β-catenin pathway regulates expression of the SOX9 gene, which encodes sex-determining region Y-box (SOX) transcription factor 9, a differentiation factor and potential β-catenin regulator. Because APC tumor suppressor defects in approximately 80% of colorectal cancers (CRCs) activate the Wnt/β-catenin pathway, we studied SOX9 inactivation in CRC biology. Compared with effects of Apc inactivation in mouse...

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PMID: 40179020
DOI: 10.1172/jci184115

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