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Article

microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer

26 May 2014

Abstract excerpt

BACKGROUND: miR-139-5p was identified to be significantly down-regulated in colon tumor tissues by miRNA array. We aimed to clarify its biological function, molecular mechanisms and direct target gene in colorectal cancer (CRC). METHODS: The biological function of miR-139-5p was examined by cell growth, cell cycle and apoptosis analysis in vitro and in vivo. miR-139-5p target gene and signaling pathway was...

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PMID: 24885920
DOI: 10.1186/1476-4598-13-124

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