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Infection and depletion of CD4+ group-1 innate lymphoid cells by HIV-1 via type-I interferon pathway

5 Jan 2018

Abstract excerpt

Innate lymphoid cells (ILCs) are severely depleted during chronic HIV-1 infection by unclear mechanisms. We report here that human ILC1s comprising of CD4+ and CD4- subpopulations were present in various human lymphoid organs but with different transcription programs and functions. Importantly, CD4+ ILC1s expressed HIV-1 co-receptors and were productively infected by HIV-1 in vitro and in vivo. Furthermore,...

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PMID: 29304123
DOI: 10.1371/journal.ppat.1006819

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