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Inflammatory Gene Expression Profile and Defective Interferon-γ and Granzyme K in Natural Killer Cells From Systemic Juvenile Idiopathic Arthritis Patients.

Arthritis & rheumatology (Hoboken, N.J.) - 1 Jan 2017

Put Karen, Vandenhaute Jessica, Avau Anneleen, van Nieuwenhuijze Annemarie, Brisse Ellen, Dierckx Tim, Rutgeerts Omer, Garcia-Perez Josselyn E, Toelen Jaan, Waer Mark, Leclercq Georges, Goris An, Van Weyenbergh Johan, Liston Adrian, De Somer Lien, Wouters Carine H, Matthys Patrick

Abstract excerpt

OBJECTIVE: Systemic juvenile idiopathic arthritis (JIA) is an immunoinflammatory disease characterized by arthritis and systemic manifestations. The role of natural killer (NK) cells in the pathogenesis of systemic JIA remains unclear. The purpose of this study was to perform a comprehensive analysis of NK cell phenotype and functionality in patients with systemic JIA. METHODS: Transcriptional alterations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27696741
DOI: 10.1002/art.39933

Genes

GZMK
TLR4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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