Article
Identification of TP53 as an acute lymphocytic leukemia susceptibility gene through exome sequencing.
Pediatric blood & cancer - 1 Jun 2013
Powell Bradford C, Jiang Lichun, Muzny Donna M, Treviño Lisa R, Dreyer Zoann E, Strong Louise C, Wheeler David A, Gibbs Richard A, Plon Sharon E
Abstract excerpt
Although acute lymphocytic leukemia (ALL) is the most common childhood cancer, genetic predisposition to ALL remains poorly understood. Whole-exome sequencing was performed in an extended kindred in which five individuals had been diagnosed with leukemia. Analysis revealed a nonsense variant of TP53 which has been previously reported in families with sarcomas and other typical Li Fraumeni syndrome-associated...
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