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Article

Self-association and conformational variation of NS5A domain 1 of hepatitis C virus.

The Journal of general virology - 1 Feb 2018

Beldar Serap, Manimekalai Malathy Sony Subramanian, Cho Nam-Joon, Baek Kwanghee, Grüber Gerhard, Yoon Ho Sup

Abstract excerpt

Direct-acting antivirals (DAAs) targeting the non-structural 5A (NS5A) protein of the hepatitis C virus (HCV) are crucial drugs that have shown exceptional clinical success in patients. However, their mode of action (MoA) remains unclear, and drug-resistant HCV strains are rapidly emerging. It is critical to characterize the behaviour of the NS5A protein in solution, which can facilitate the development of new...

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Identifiers

PMID: 29300159
DOI: 10.1099/jgv.0.001000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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