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Article

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors.

Protein science : a publication of the Protein Society - 1 Jun 2014

Lambert Sebastian M, Langley David R, Garnett James A, Angell Richard, Hedgethorne Katy, Meanwell Nicholas A, Matthews Steve J

Abstract excerpt

New direct acting antivirals (DAAs) such as daclatasvir (DCV; BMS-790052), which target NS5A function with picomolar potency, are showing promise in clinical trials. The exact nature of how these compounds have an inhibitory effect on HCV is unknown; however, major resistance mutations appear in the N-terminal region of NS5A that include the amphipathic helix and domain 1. The dimeric symmetry of these compounds...

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Identifiers

PMID: 24639329
DOI: 10.1002/pro.2456
PMCID: PMC4093949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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