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Article

De novo polymerase activity and oligomerization of hepatitis C virus RNA-dependent RNA-polymerases from genotypes 1 to 5.

PloS one - 7 Apr 2011

Clemente-Casares Pilar, López-Jiménez Alberto J, Bellón-Echeverría Itxaso, Encinar José Antonio, Martínez-Alfaro Elisa, Pérez-Flores Ricardo, Mas Antonio

Abstract excerpt

Hepatitis C virus (HCV) shows a great geographical diversity reflected in the high number of circulating genotypes and subtypes. The response to HCV treatment is genotype specific, with the predominant genotype 1 showing the lowest rate of sustained virological response. Virally encoded enzymes are candidate targets for intervention. In particular, promising antiviral molecules are being developed to target the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21490973
DOI: 10.1371/journal.pone.0018515
PMCID: PMC3072391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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