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Article

Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA.

Scientific reports - 23 Apr 2014

Ascher David B, Wielens Jerome, Nero Tracy L, Doughty Larissa, Morton Craig J, Parker Michael W

Abstract excerpt

Hepatitis C virus (HCV) infection affects more than 170 million people. The high genetic variability of HCV and the rapid development of drug-resistant strains are driving the urgent search for new direct-acting antiviral agents. A new class of agents has recently been developed that are believed to target the HCV protein NS5A although precisely where they interact and how they affect function is unknown. Here we...

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Share to Antiviral Agents
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24755925
DOI: 10.1038/srep04765
PMCID: PMC3996483

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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