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Article

Overall Structural Model of NS5A Protein from Hepatitis C Virus and Modulation by Mutations Confering Resistance of Virus Replication to Cyclosporin A.

Biochemistry - 20 Jun 2017

Badillo Aurelie, Receveur-Brechot Véronique, Sarrazin Stéphane, Cantrelle François-Xavier, Delolme Frédéric, Fogeron Marie-Laure, Molle Jennifer, Montserret Roland, Bockmann Anja, Bartenschlager Ralf, Lohmann Volker, Lippens Guy, Ricard-Blum Sylvie, Hanoulle Xavier, Penin François

Abstract excerpt

Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a RNA-binding phosphoprotein composed of a N-terminal membrane anchor (AH), a structured domain 1 (D1), and two intrinsically disordered domains (D2 and D3). The knowledge of the functional architecture of this multifunctional protein remains limited. We report here that NS5A-D1D2D3 produced in a wheat germ cell-free system is obtained under a highly...

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PMID: 28535337
DOI: 10.1021/acs.biochem.7b00212

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