Article
Molecular-interaction and signaling profiles of AM3677, a novel covalent agonist selective for the cannabinoid 1 receptor.
ACS chemical neuroscience - 19 Aug 2015
Janero David R, Yaddanapudi Suma, Zvonok Nikolai, Subramanian Kumar V, Shukla Vidyanand G, Stahl Edward, Zhou Lei, Hurst Dow, Wager-Miller James, Bohn Laura M, Reggio Patricia H, Mackie Ken, Makriyannis Alexandros
Abstract excerpt
The cannabinoid 1 receptor (CB1R) is one of the most abundant G protein-coupled receptors (GPCRs) in the central nervous system. CB1R involvement in multiple physiological processes, especially neurotransmitter release and synaptic function, has made this GPCR a prime drug discovery target, and pharmacological CB1R activation has been demonstrated to be a tenable therapeutic modality. Accordingly, the design and...
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