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Article

Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4.

Development (Cambridge, England) - 1 Oct 2003

Blackshear Perry J, Graves Joan P, Stumpo Deborah J, Cobos Inma, Rubenstein John L R, Zeldin Darryl C

Abstract excerpt

One line of mice harboring a cardiac-specific epoxygenase transgene developed head swelling and rapid neurological decline in young adulthood, and had marked hydrocephalus of the lateral and third ventricles. The transgene was found to be inserted into an intron in the mouse Rfx4 locus. This insertion apparently prevented expression of a novel variant transcript of RFX4 (RFX4_v3), a member of the regulatory...

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Identifiers

PMID: 12925582
DOI: 10.1242/dev.00661

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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