Article
Characterization of a candidate tetravalent vaccine based on 2'-O-methyltransferase mutants.
PloS one - 1 Jan 2018
Züst Roland, Li Shi-Hua, Xie Xuping, Velumani Sumathy, Chng Melissa, Toh Ying-Xiu, Zou Jing, Dong Hongping, Shan Chao, Pang Jassia, Qin Cheng-Feng, Newell Evan W, Shi Pei-Yong, Fink Katja
Abstract excerpt
Dengue virus (DENV) is one of the most widespread arboviruses. The four DENV serotypes infect about 400 million people every year, causing 96 million clinical dengue cases, of which approximately 500'000 are severe and potentially life-threatening. The only licensed vaccine has a limited efficacy and is only recommended in regions with high endemicity. We previously reported that 2'-O-methyltransferase mutations...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.