Article
Variation analysis of PUM1 gene in Chinese women with primary ovarian insufficiency.
Journal of assisted reproduction and genetics - 1 Apr 2018
Luo Wei, Ke Hanni, Liu Ran, Qin Yingying, Mak Winifred, Ma Jinlong, Zhao Shidou, Chen Zi-Jiang
Abstract excerpt
Accumulating evidence has indicated that the genes involved in meiosis are highly correlated with ovarian function. Pumilio 1 (PUM1) is a RNA-binding protein which is involved in the meiotic process. It has been reported that the Pum1 knockout female mice displayed subfertility due to the decrease in primordial follicle pool. The aim of our study is to investigate whether variants of the PUM1 gene are responsible...
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