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Article

Variation analysis of PRIM1 gene in Chinese patients with primary ovarian insufficiency.

Reproductive biomedicine online - 1 Nov 2016

Wang Wenting, Cheng Lei, Zhang Jiangtao, Qin Yingying, Zhao Shidou, Chen Zi-Jiang

Abstract excerpt

Insights into common genetic susceptibility between primary ovarian insufficiency (POI) and natural or early menopause have delivered an innovative way of assessing the genetic mechanisms involved in POI. PRIM1 plays a crucial role in DNA replication by synthesizing RNA primers for Okazaki fragments. It is closely associated with age at natural menopause, early menopause and POI in European women. In this study,...

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Source

Identifiers

PMID: 27599756
DOI: 10.1016/j.rbmo.2016.08.017

Genes

PRIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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