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Article

New candidate gene POU5F1 associated with premature ovarian failure in Chinese patients.

Reproductive biomedicine online - 1 Mar 2011

Wang Jing, Wang Binbin, Song Junjie, Suo Peisu, Ni Feng, Chen Beili, Ma Xu, Cao Yunxia

Abstract excerpt

Premature ovarian failure (POF) is defined as a cessation of ovarian function in women before the age of 40 years. POU5F1 has a critical role in regulating pluripotency in embryonic development and POU5F1 transcription factor is down-regulated more than 30-fold in the POF candidate gene Nobox knockout ovaries. In order to identify the potential correlation between POU5F1 and the development of POF, the exon...

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PMID: 21273125
DOI: 10.1016/j.rbmo.2010.11.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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