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Article

Diet1, bile acid diarrhea, and FGF15/19: mouse model and human genetic variants.

Journal of lipid research - 1 Mar 2018

Lee Jessica M, Ong Jessica R, Vergnes Laurent, de Aguiar Vallim Thomas Q, Nolan Jonathan, Cantor Rita M, Walters Julian R F, Reue Karen

Abstract excerpt

Diet1 modulates intestinal production of the hormone, fibroblast growth factor (FGF)15, which signals in liver to regulate bile acid synthesis. C57BL/6ByJ mice with a spontaneous Diet1-null mutation are resistant to hypercholesterolemia compared with wild-type C57BL/6J mice through enhanced cholesterol conversion to bile acids. To further characterize the role of Diet1 in metabolism, we generated Diet1-/- mice on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29295820
DOI: 10.1194/jlr.M078279
PMCID: PMC5832924

Genes

BAD
FGF19

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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