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Article

Prospective Evaluation of Cetuximab-Mediated Antibody-Dependent Cell Cytotoxicity in Metastatic Colorectal Cancer Patients Predicts Treatment Efficacy.

Cancer immunology research - 1 Apr 2016

Trotta Anna Maria, Ottaiano Alessandro, Romano Carmela, Nasti Guglielmo, Nappi Anna, De Divitiis Chiara, Napolitano Maria, Zanotta Serena, Casaretti Rossana, D'Alterio Crescenzo, Avallone Antonio, Califano Daniela, Iaffaioli Rosario Vincenzo, Scala Stefania

Abstract excerpt

Cetuximab is a monoclonal antibody to the EGFR that induces antibody-dependent cell cytotoxicity (ADCC) through Fcγ receptors on immune cells. Although SNPs in genes encoding Fcγ receptors are functionally relevant to cetuximab-mediated ADCC in colorectal cancer, a direct correlation between in vitro ADCC and clinical response to cetuximab is not defined. We therefore enrolled 96 consecutive metastatic colorectal...

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Identifiers

PMID: 26817995
DOI: 10.1158/2326-6066.CIR-15-0184

Genes

EGFR
KRAS

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