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Article

Putative contribution of CD56 positive cells in cetuximab treatment efficacy in first-line metastatic colorectal cancer patients.

BMC cancer - 30 Jun 2010

Maréchal Raphaël, De Schutter Jef, Nagy Nathalie, Demetter Pieter, Lemmers Arnaud, Devière Jacques, Salmon Isabelle, Tejpar Sabine, Van Laethem Jean-Luc

Abstract excerpt

BACKGROUND: Activity of cetuximab, a chimeric monoclonal antibody targeting the epidermal growth factor receptor, is largely attributed to its direct antiproliferative and proapoptotic effects. Antibody-dependent cell-mediated cytotoxicity (ADCC) could be another possible mechanism of cetuximab antitumor effects and its specific contribution on the clinical activity of cetuximab is unknown. METHODS: We assessed...

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Share to Antibodies, Monoclonal, Humanized
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20591136
DOI: 10.1186/1471-2407-10-340
PMCID: PMC2912265

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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