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Article

Multi-trait analysis of genome-wide association summary statistics using MTAG.

Nature genetics - 1 Feb 2018

Turley Patrick, Walters Raymond K, Maghzian Omeed, Okbay Aysu, Lee James J, Fontana Mark Alan, Nguyen-Viet Tuan Anh, Wedow Robbee, Zacher Meghan, Furlotte Nicholas A, Magnusson Patrik, Oskarsson Sven, Johannesson Magnus, Visscher Peter M, Laibson David, Cesarini David, Neale Benjamin M, Benjamin Daniel J

Abstract excerpt

We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary statistics from genome-wide association studies (GWAS) of different traits, possibly from overlapping samples. We apply MTAG to summary statistics for depressive symptoms (N eff = 354,862), neuroticism (N = 168,105), and subjective well-being (N = 388,538). As compared to the 32, 9, and 13 genome-wide significant loci...

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Identifiers

PMID: 29292387
DOI: 10.1038/s41588-017-0009-4
PMCID: PMC5805593

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