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Article

Trait selection strategy in multi-trait GWAS: Boosting SNP discoverability.

HGG advances - 18 Jul 2024

Suzuki Yuka, Ménager Hervé, Brancotte Bryan, Vernet Raphaël, Nerin Cyril, Boetto Christophe, Auvergne Antoine, Linhard Christophe, Torchet Rachel, Lechat Pierre, Troubat Lucie, Cho Michael H, Bouzigon Emmanuelle, Aschard Hugues, Julienne Hanna

Abstract excerpt

Since the first genome-wide association studies (GWASs), thousands of variant-trait associations have been discovered. However, comprehensively mapping the genetic determinant of complex traits through univariate testing can require prohibitive sample sizes. Multi-trait GWAS can circumvent this issue and improve statistical power by leveraging the joint genetic architecture of human phenotypes. Although many...

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Share to Genome-Wide Association Study
Share to Models, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait, Heritable

Share to Quantitative Trait Loci

Source

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Identifiers

PMID: 38872309
DOI: 10.1016/j.xhgg.2024.100319
PMCID: PMC11260573

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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