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Article

Hypermethylation of MEG3 promoter correlates with inactivation of MEG3 and poor prognosis in patients with retinoblastoma

1 Dec 2017

Abstract excerpt

BACKGROUND: In our previous study, we revealed that MEG3 was a tumor suppressor gene in retinoblastoma and inhibited proliferation of retinoblastoma cells by regulating the activity of the Wnt/β-catenin pathway. Here, we further explored the mechanism of MEG3 inactivation in retinoblastoma. METHODS: MSP and qRT-PCR were performed to detect the methylation status of MEG3 promoter and levels of MEG3 expression,...

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PMID: 29287592
DOI: 10.1186/s12967-017-1372-8

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