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Article

Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors.

The Journal of clinical endocrinology and metabolism - 1 Apr 2005

Zhao Jing, Dahle Danielle, Zhou Yunli, Zhang Xun, Klibanski Anne

Abstract excerpt

MEG3 is a human homolog of the mouse maternal imprinted gene, Gtl2. Gtl2 has been suggested to be involved in fetal and postnatal development and to function as an RNA. Recently our laboratory demonstrated that a cDNA isoform of MEG3, MEG3a, inhibits cell growth in vitro. Interestingly, MEG3 is highly expressed in the normal human pituitary. In striking contrast, no MEG3 expression was detected in human...

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Identifiers

PMID: 15644399
DOI: 10.1210/jc.2004-1848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hypermethylation of the promoter region is associated with the loss of MEG3 gene expression in human pituitary tumors.PMID 15644399Read ↗

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